MADISON, WI USA (May 22, 2026) Porta Sophia filed a third-party preissuance submission with the United States Patent and Trademark Office (USPTO) today for U.S. Pat. App. Ser. No. 19/283,158 entitled “METHODS OF TREATMENT WITH COMBINATIONS OF CANNABIDIOL AND PSILOCYBIN”, which is currently assigned to ECP Pharma. The submission consisted of four prior art documents that are material to the patentability of one claim of the application.
Porta Sophia, a non-profit psychedelic prior art library, leverages the experience of legal and interdisciplinary academic scholars to promote an ethical psychedelic patenting landscape that preserves the integrity of the public domain. The organization curates and makes relevant historical documentation readily available for anyone wanting to explore the scope of psychedelic technologies, including patent examiners.
Patent application: CBD and psilocybin combination treatment
The ’158 application was filed on July 28, 2025 and claims priority to a provisional application filed on October 13, 2021. It describes treating brain injuries, namely TBI, using CBD and psilocybin. The doses of both CBD and psilocybin are oral and administered at the same time.
Prior art in the third-party preissuance submission included publications from peer reviewed journals, web pages, and international patent documents. This prior art anticipates claims in the ’158 application. The full third-party submission documentation is available here.
Third-party submissions of prior art
United States patent law allows third parties to submit prior art and concise descriptions of their relevance to the USPTO. Documents submitted may be considered in the examination of that patent application. In addition, these submissions have a broad impact because applicants have a duty to disclose the prior art submitted against a single patent application for other relevant patent applications filed by the applicant.
Porta Sophia tracks and analyzes psychedelic patent applications globally. If an application improperly claims innovation of something known in the public domain and meets the standards of Porta Sophia's third party intervention evaluation criteria, the team assembles evidence against these invalid claims and contests them directly to the relevant patent office through third-party interventions.
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